As German Chancellor Angela Merkel enters her fourth term in office, the US-German relationship will need to overcome trade and policy disagreements in order to thrive in today’s uncertain political climate. The administrations in Berlin and Washington, DC should seek new opportunities for closer cooperation, particularly related to security around NATO, policy toward Russia, bilateral trade, and the energy sector. The shared interests of the United States and Germany should drive both administrations to pursue these areas of cooperation in order to strengthen the alliance on which they will continue to depend as the world grows more insecure and the challenges more complex.