In cybersecurity, it is time to go beyond sharing and ad hoc cooperation, to collaboration at scale across borders, stakeholders, and sectors. This effort should begin with a determined study of the responses to past incidents and how to improve them, then proceed to new, action-oriented Cyber Incident Collaboration Organizations (CICO) to streamline response. The goal of a CICO must be to streamline the current response process for an incident type, to provide an umbrella to make such work easier or to upscale it. In this issue brief, Jason Healey presents the next generation of innovations that will simplify agile, scalable response to incidents—across borders, stakeholders, and sectors.